Minoxidil/Spironolactone
Compound
Serum
Foam
Oral
Your provider will determine the dosage based on your hair re-growth goals and medical history.
Minoxidil/Spironolactone Compound
Spironolactone can benefit women with female pattern hair loss by slowing hair loss and promoting new growth when used long-term. Spironolactone works by blocking androgen receptors and inhibiting the production of male hormones like testosterone and dihydrotestosterone (DHT).
Spironolactone is particularly effective when combined with minoxidil
How the compound works
The combination of minoxidil and spironolactone addresses hair loss in two key ways:
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Spironolactone (anti-androgen): Blocks androgens, such as dihydrotestosterone (DHT), which can shrink hair follicles and cause thinning. It is particularly effective for women with hormone-related hair loss, such as that caused by polycystic ovary syndrome (PCOS) or menopause.
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Minoxidil (vasodilator): Increases blood flow and nutrient delivery to hair follicles, which helps prolong the anagen (growth) phase of the hair cycle. This promotes new growth and improves the thickness of existing hair.
Benefits and effectiveness
Combining the two medications offers a comprehensive approach to treating FPHL:
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Better results: Several studies have shown that combining minoxidil and spironolactone is significantly more effective than using either medication alone. One study found that 70% of patients using the combination showed improved hair density, compared to only 33% using minoxidil with finasteride.
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Dual action: By tackling both hormonal and circulatory causes of hair loss, the compound provides a more powerful and targeted treatment.
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Increased hair density: The synergistic effect often leads to noticeable improvements in hair density and reduced shedding.
Potential side effects
The side effects vary based on whether the medication is topical or oral. Oral spironolactone carries a higher risk of systemic side effects.
Common topical side effects:
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Scalp irritation: Redness, itching, dryness, or a burning sensation can occur, especially with the 5% minoxidil solution.
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Contact dermatitis: The vehicle ingredients in topical products, such as propylene glycol, can cause a rash.
Common oral side effects:
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Dizziness and lightheadedness: Caused by lowered blood pressure.
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Menstrual irregularities: Spironolactone can affect hormone levels, leading to irregular periods.
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Breast tenderness: Breast tissue sensitivity is another potential hormonal side effect.