Tadalafil (Cialis)
Oral medication
2.5 MG / 5 MG / 10 MG /20 MG
Dosage determined by your provider based on you sex health goals and medical history.
Tadalafil
is an FDA-approved medication to treat erectile dysfunction (ED) by increasing blood flow to the penis. Its long-lasting effect provides sexual benefits that include greater spontaneity and increased satisfaction. Tadalafil can also improve sexual function in men with premature ejaculation.
Benefits for Erectile Dysfunction (ED)
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Improves erectile response: Tadalafil enhances the body's natural erectile response when a man is sexually stimulated.
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Long-lasting effect: Tadalafil can remain active in the body for up to 36 hours, giving it a longer duration than other PDE5 inhibitors like sildenafil (Viagra). This provides more flexibility and spontaneity.
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Psychological benefits: Some studies suggest tadalafil may be linked to improved self-esteem and other psychological factors associated with ED.
How tadalafil works for erectile dysfunction (ED)
For an erection to occur, sexual arousal is necessary. Arousal triggers the release of nitric oxide, which leads to the production of a chemical called cyclic guanosine monophosphate (cGMP).
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Nitric oxide release: Sexual stimulation causes nerves in the penis to release nitric oxide.
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Increased cGMP levels: The nitric oxide signals the production of cGMP, which relaxes the smooth muscle cells in the arteries of the penis.
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Increased blood flow: The relaxed arteries allow for greater blood flow into the penis, causing it to become erect.
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PDE5's role: The enzyme PDE5 is naturally present to break down cGMP, which ends the erection.
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Tadalafil's action: Tadalafil blocks the PDE5 enzyme, preventing it from breaking down cGMP. This allows cGMP to accumulate and the muscles in the blood vessels to remain relaxed, sustaining the erection.
It is important to remember that tadalafil does not cause a spontaneous erection. Sexual stimulation is still required for the process to begin.
Other Health Benefits
Benign Prostatic Hyperplasia (BPH)
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Relieves urinary symptoms: Tadalafil is FDA-approved to treat the urinary symptoms of an enlarged prostate, such as frequent or difficult urination.
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Relaxed muscles: It works by relaxing the smooth muscles in the prostate and bladder, which reduces pressure on the urethra and makes urination easier.
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Treats co-existing conditions: Tadalafil is particularly beneficial for men who have both BPH and ED.
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Pulmonary Arterial Hypertension (PAH)
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Lowers blood pressure in the lungs: Tadalafil relaxes the blood vessels in the chest, increasing blood supply to the lungs and reducing the workload on the heart.
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Improves exercise capacity: By improving blood flow, the medication can enhance the ability to exercise in both men and women with PAH.
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Potential broader health benefits
Recent research also suggests that tadalafil may have benefits beyond its primary uses, but these require further investigation.
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Cardiovascular health: Some studies have linked the use of tadalafil and sildenafil in men with ED to improved cardiovascular outcomes and lower risks of heart attack and stroke.
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Anti-aging and cognitive effects: Emerging research suggests that a low daily dose of tadalafil could have anti-aging and cognitive benefits.
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Reduced mortality: Studies have observed reduced all-cause mortality in patients with erectile dysfunction who were treated with tadalafil.
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Reduced dementia risk: Some research indicates a lower risk of dementia in individuals taking tadalafil.
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