Sildenafil (Viagra)
Oral Medication
20 MG / 25 MG / 50 MG / 100 MG
Dosage determined by your provider based on you sex health goals and medical history.
Sildenafil
Sildenafil is an FDA-approved prescription medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor. When sexually stimulated, sildenafil increases blood flow to the penis, helping men achieve and sustain an erection.
Key benefits of sildenafil
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Rapid onset of action: An erection can occur as early as 12 to 27 minutes after taking the dose, with peak concentrations typically reached within one hour.
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Sildenafil is effective for men with ED of organic, psychogenic, or mixed origins. It works in many patients, including those with conditions like diabetes mellitus and after radical prostatectomy, although efficacy may be lower in these populations.
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Clinical studies show that sildenafil significantly improves the ability to achieve and maintain an erection sufficient for intercourse.
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The therapeutic window of opportunity to engage in sexual intercourse can be maintained for up to 4 to 5 hours after administration.
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Treatment with sildenafil can significantly improve self-esteem, sexual relationship satisfaction, and overall quality of life for men with ED and their partners.
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As an oral tablet, sildenafil is a discreet, non-invasive treatment option compared to older methods like injections or penile implants.
How sildenafil works for ED
For an erection to occur, the body releases nitric oxide (NO), which signals the production of cyclic guanosine monophosphate (cGMP). The cGMP relaxes the smooth muscles in the penis, allowing blood vessels to widen and fill with blood.
Sildenafil enhances this natural process by acting as a phosphodiesterase-5 (PDE5) inhibitor. By blocking the PDE5 enzyme, sildenafil prevents the breakdown of cGMP, causing an increase in cGMP levels and amplifying the NO-cGMP signaling pathway.
Other important health benefits of sildenafil
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Pulmonary arterial hypertension (PAH): By relaxing the pulmonary arteries, it reduces blood pressure in the lungs, making it easier for the heart to pump blood and improving exercise capacity.
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Lower urinary tract symptoms (LUTS): For men with benign prostatic hyperplasia (BPH), sildenafil can improve urinary tract function.
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Cardiovascular health: Sildenafil has demonstrated several cardioprotective effects in studies.
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A large scale 2025 sildenafil was shown to reduce the risk of dementia.
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Research indicates sildenafil may help reduce inflammation, oxidative stress, aSildenafil has been shown to improve skeletal muscle oxygenation and increase muscle protein synthesis, which can lead to longer, harder workouts for gym-goers. nd chronic neuropathic pain.
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